Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Test Data Available. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. G2W4de=u183KGH{ vQ#4:1\wc : 1. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. CAS 9004-34-6. SDS - Safety Data Sheet. The typical mean particle size is 20200 m. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Product and Company Identification . Synonyms: Cellulose, Cellulose powder, Cotton linters. 8 0 obj INCI. EINECS #: 232-674-9 1.7. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? BIOACCUMULATIVE POTENTIAL MATERIAL SAFETY DATA SHEET. : 160182 Date Approved: 05/25/2010 Revision No. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. Packaging: 34 x 50 kgs fiber drums. The data shown below apply only to Avicel PH 101. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Revision No. Aqueous suspensions of microcrystalline cellulose have . endobj Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . No. CAS 9004-34-6, pH 5 - 7.5. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. ( Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm 130. l~5C The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. Truly distinctive drug delivery solutions. In extrusion-spheronisation, it is the excipient of choice. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Molecular weight: Not Applicable 1.5. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Battista, O. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ }o]X4]. CAS #: 9004-34-6 A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. % Buy Chemicals. CAS No. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Document(s): certificate data msds. Product Name: Microcrystalline Cellulose 1.2. % Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Synergies to simplify formulation challenges and reduce operational costs. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. A., and Smith, P. A. /Type/Page 1 0 obj Quantity: 1 700 kgs. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Manufacturer: FMC BioPolymer. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. MSDS Ref. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. We know that our customers need to provide reliable and consistent products to their patients. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. CAS #: 9004-34-6 1.6. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? common form is used in vitamin supplements or tablets. ). Molecular weight: Not Applicable 1.5. Combines good flow and high compactibility. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. These, in turn, are assembled into fibrils in the cell wall. SDS. Microcrystalline Cellulose NF. Avicel PC 611 (FMC Biopolymer) . ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. The aqueous solution to barrier membrane coating. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Wu, K. Zuurman, H.W. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Home. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. P}MFbN#[>r(y JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. /Contents 4 0 R {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. stream Regulatory Information if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. << {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. : 9004-34-6 Date Approved: 01/31/2008 . We can send by Fedex, by ship or by plane according to international rules. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. . w !1AQaq"2B #3Rbr q86@on$^X_HuH;3` 2 0 obj In 1964 FMC, Corporation . The figure below illustrates the structural organisation of cellulose within plants. *r_ *?~4$ &0Y# Microcrystalline cellulose is a commonly used excipient in the . TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. Van Veen, G.K. Bolhuis, Y.S. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. >> 0.25 - 0.37. 5 0 obj Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Heavy metals, % NMT 0.001 The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. We are artists at heart and creators by nature. Alginates also function as actives in some anti-reflux products. Have an order or account question? X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . /Parent 3 0 R The most. No. endobj stream Your file is uploaded and ready to be published. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Looking for FMC'searnings news? Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Catalog Number 102331. %PDF-1.3 Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed.